In addition to Ryan, Crystal and his wife Janice also shared a touching tribute to Reiner in a heartfelt statement signed by several of Rob and Michele's close friends, including Larry David, Martin Short, Albert Brooks and more.

"His comedic touch was beyond compare, his love of getting the music of the dialogue just right, and his sharpening of the edge of a drama was simply elegant," the statement read, in part. "For the actors, he loved them. For the writers he made them better. His greatest gift was freedom. If you had an idea, he listened, he brought you into the process. They always felt they were working as a team. To be in his hands as a film maker was a privilege but that is only part of his legacy."

Rob previously shared how his now-wife inspired him to change the ending of When Harry Met Sally, in which he originally had the characters going their separate ways, per Page Six.

"I met her while we were making the film, and I changed the ending," he said in a 2018 interview with the Guardian. "Originally, Harry and Sally didn't get together. But then I met Michele and I thought: OK, I see how this works."

Rob and Michele Reiner, who were married for 36 years, were found dead in their home on Sunday (December 14). Their son Nick Reiner, 32, has been charged with two counts of first degree murder in connection with their stabbing deaths and made an appearance in court on Wednesday (December 17). He is being held without bail and his arraignment has been postponed until January 7, 2026.

The Reiners' other two children, daughter Romy, 28, and son Jake, 34, broke their silence on their parents’ deaths in an emotional statement on Wednesday.

"Words cannot even begin to describe the unimaginable pain we are experiencing every moment of the day. The horrific and devastating loss of our parents, Rob and Michele Reiner, is something that no one should ever experience. They weren't just our parents; they were our best friends," they said. "We are grateful for the outpouring of condolences, kindness, and support we have received not only from family and friends but people from all walks of life."

They added, "We now ask for privacy, for speculation to be tempered with compassion and humanity, and for our parents to be remembered for the incredible lives they lived and the love they gave."